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primidone will lower the level or impact of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.posaconazole will boost the level or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.drospirenone will raise the degree or effect of modafinil by affecting hepa